Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.74 |
| ▸ | PDE4A | P27815 | 2/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.74 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473004 | 0.91 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL6386266 | 0.88 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1824084 | 0.86 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL4187551 | 0.86 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL8317685 | 0.86 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL447418 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL26718 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL4187035 | 0.85 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL29651667 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL7204721 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | claimed |
| EP-1725534-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-29 | — | — | EP | claimed |
| WO-2005087745-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-22 | — | — | WO | claimed |
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185149-A1 | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors | PDE4A, PDE4B, PDE4C | PDE4D 4/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.