Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30453819 | 0.97 | MET (0.72) | METJAK2ALK | |
| SCHEMBL488474 | 0.97 | MET (0.72) | METJAK2ALK | |
| SCHEMBL488726 | 0.92 | MET (0.80) | METJAK2ALK | |
| SCHEMBL30454264 | 0.92 | MET (0.80) | METJAK2ALK | |
| SCHEMBL30453859 | 0.86 | MET (0.80) | METJAK2ALK | |
| SCHEMBL488107 | 0.86 | MET (0.80) | METJAK2ALK | |
| SCHEMBL30452648 | 0.84 | MET (0.77) | METJAK2ALK | |
| SCHEMBL488285 | 0.84 | MET (0.77) | METJAK2ALK | |
| SCHEMBL488761 | 0.83 | MET (0.73) | METJAK2ALK | |
| SCHEMBL30454551 | 0.83 | MET (0.73) | METJAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | claimed |