Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010206 | 0.87 | TSHR (0.46) | ALDH1A1MAPTMEN1KMT2ACA12 | |
| SCHEMBL332380 | 0.75 | MAPT (0.62) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL983425 | 0.75 | CYP1A2 (0.57) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4001073 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL11417093 | 0.74 | MAPT (0.61) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL18050572 | 0.74 | TSHR (0.44) | ALDH1A1MAPTMEN1KMT2ACA12 | |
| SCHEMBL26103781 | 0.73 | CA12 (0.66) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4625676 | 0.73 | TSHR (0.56) | ALDH1A1MAPTMEN1KMT2ACA12 | |
| SCHEMBL1546638 | 0.72 | CYP2C19 (0.49) | ALDH1A1MAPTKDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL5312956 | 0.72 | CA12 (0.68) | MEN1KMT2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753727-A1 | NOVEL CIS-IMIDAZOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005110996-A1 | NOVEL CIS-IMIDAZOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-11-24 | — | — | WO | disclosed |