Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 11/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457199 | 0.88 | PIK3CA (0.55) | PIK3CAACACBPIK3CDMEN1USP2 | |
| SCHEMBL20000530 | 0.83 | PIK3CA (0.51) | PIK3CAACACBPIK3CDMEN1USP2 | |
| SCHEMBL19725018 | 0.81 | PIK3CA (0.49) | PIK3CAACACBPIK3CDMEN1USP2 | |
| SCHEMBL1123812 | 0.78 | MAPT (0.58) | PIK3CAPIK3CDALDH1A1TSHRHSD17B10 | |
| SCHEMBL9893154 | 0.77 | ACACB (0.45) | PIK3CAACACBPIK3CDPIK3R1PIK3CB | |
| SCHEMBL22616878 | 0.76 | KMT2A (0.78) | PIK3CAMEN1USP2ALDH1A1ALOX15 | |
| SCHEMBL30818913 | 0.76 | ACACB (0.54) | ACACBPIK3CBUSP30 | |
| SCHEMBL30818658 | 0.75 | HRH3 (0.51) | PIK3CAPIK3CDALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL5525967 | 0.75 | PIK3CA (0.58) | PIK3CAPIK3CDALDH1A1PIK3R1PIK3CB | |
| SCHEMBL9893036 | 0.75 | ACACB (0.44) | PIK3CAACACBPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |