Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 8/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489122 | 0.92 | SSTR5 (0.46) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5486209 | 0.91 | SSTR5 (0.47) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL1380432 | 0.91 | SSTR5 (0.45) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5485488 | 0.91 | SSTR5 (0.57) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5479667 | 0.91 | SSTR5 (0.47) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5484896 | 0.89 | SSTR5 (0.46) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5478929 | 0.89 | SSTR5 (0.48) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5487207 | 0.87 | SSTR5 (0.40) | SSTR5HRH1HTTKCNH2SSTR1 | |
| SCHEMBL5486159 | 0.86 | SSTR5 (0.49) | SSTR5HRH1HTTKCNH2LMNA | |
| SCHEMBL5478905 | 0.86 | SSTR5 (0.42) | SSTR5HRH1HTTKCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |