Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485393 | 0.89 | USP30 (0.43) | MAPTTSHRNPC1SMN1; SMN2MEN1 | |
| SCHEMBL4338428 | 0.85 | MAPT (0.44) | MAPTTSHRNPC1SMN1; SMN2MEN1 | |
| SCHEMBL1544442 | 0.83 | KCNH2 (0.47) | MAPTTSHRNPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL5478892 | 0.82 | MAPT (0.40) | MAPTTSHRNPC1SMN1; SMN2MEN1 | |
| SCHEMBL4336808 | 0.82 | MAPT (0.38) | MAPTTSHRNPC1SMN1; SMN2SMPD1 | |
| SCHEMBL5482293 | 0.81 | P2RX7 (0.40) | MAPTTSHRNPC1SMN1; SMN2TP53 | |
| SCHEMBL4232705 | 0.81 | MAPT (0.41) | MAPTNPC1SMPD1L3MBTL1TP53 | |
| SCHEMBL4327916 | 0.81 | KCNH2 (0.47) | MAPTTSHRNPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4333880 | 0.81 | MAPT (0.36) | MAPTTSHRNPC1SMN1; SMN2MEN1 | |
| SCHEMBL5484553 | 0.79 | GRM5 (0.51) | MAPTNPC1SMPD1L3MBTL1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| WO-2007130824-A2 | FUSED HETEROCYLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | GRM5, GRIK5, GRM2 | MAPT 711/4885TSHR 1183/4885NPC1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.