Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cannabidiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 known ✓ | P21554 | 11/20 | 0.67 |
| ▸ | CNR2 | P34972 | 15/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.67 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.67 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.67 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.67 |
| ▸ | TRPV2 | Q9Y5S1 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.67 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.65 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dronabinol SCHEMBL9746995 | 0.86 | CNR2 (0.75) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL29350505 | 0.82 | CNR2 (1.00) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL29433714 | 0.82 | CNR2 (1.00) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL29815206 | 0.82 | CNR2 (1.00) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL121085 | 0.82 | CNR2 (1.00) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL23460333 | 0.82 | CNR2 (1.00) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| SCHEMBL24713687 | 0.81 | CNR2 (0.98) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| SCHEMBL29814956 | 0.81 | CNR2 (0.98) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| SCHEMBL24714648 | 0.81 | CNR2 (0.98) | CNR2CNR1TRPV1OPRM1CYP1A1 | |
| Cannabinol SCHEMBL28565069 | 0.81 | CNR2 (0.98) | CNR2CNR1TRPV1OPRM1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| EP-1368663-A2 | NOVEL REAGENTS FOR DETECTING CANNABINOIDS | Lifepoint, Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002073214-A2 | NOVEL REAGENTS FOR DETECTING CANNABINOIDS | LIFEPOINT, INC. (US) | 2002-09-19 | — | — | WO | disclosed |