Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.57 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.57 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL5487457 | 0.87 | GABBR2 (0.57) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| E968 SCHEMBL5488331 | 0.87 | GABBR2 (0.57) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| Propylene Glycol SCHEMBL5485220 | 0.86 | TDP1 (0.48) | GABBR2GABBR1GABRR1TDP1TRPM8 | |
| SCHEMBL5492126 | 0.86 | GABBR2 (0.52) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| 1,3-Butanediol SCHEMBL5484496 | 0.86 | GABBR2 (0.52) | GABBR2GABBR1GABRR1TDP1TRPM8 | |
| SCHEMBL5482004 | 0.83 | GABBR2 (0.53) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| SCHEMBL497185 | 0.83 | GABBR2 (0.76) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| SCHEMBL1359576 | 0.83 | GABBR2 (0.52) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| Ethylene Glycol SCHEMBL5491034 | 0.81 | GABBR2 (0.67) | GABBR2GABBR1GABRR1TRPM8LPAR3 | |
| SCHEMBL673559 | 0.81 | GABBR2 (0.73) | GABBR2GABBR1GABRR1TRPM8LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087270-A1 | NONAQUEOUS ELECTROLYTE SOLUTION AND NONAQUEOUS ELECTROLYTE SOLUTION SECONDARY BATTERY EMPLOYING THE SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-04-19 | — | — | US | disclosed |
| US-7169511-B2 | Nonaqueous electrolyte solution and nonaqueous electrolyte solution secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-01-30 | — | — | US | disclosed |
| EP-1555711-A1 | NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY CONTAINING THE SAME | Mitsubishi Chemical Corporation (JP) | 2005-07-20 | — | — | EP | disclosed |
| US-20050014071-A1 | Nonaqueous electrolyte solution and nonaqueous electrolyte solution secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-01-20 | — | — | US | disclosed |