Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 9/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438651 | 1.00 | MAPT (0.43) | MAPTKCNH2LMNASMN1; SMN2GRM5 | |
| SCHEMBL5483157 | 1.00 | MAPT (0.43) | MAPTKCNH2LMNASMN1; SMN2GRM5 | |
| SCHEMBL5486686 | 0.91 | GRM5 (0.42) | MAPTLMNASMN1; SMN2GRM5HCRTR1 | |
| SCHEMBL5435557 | 0.90 | GRM5 (0.36) | LMNASMN1; SMN2GRM5 | |
| SCHEMBL5485273 | 0.88 | GRM5 (0.42) | MAPTLMNASMN1; SMN2GRM5HCRTR1 | |
| SCHEMBL5442569 | 0.88 | GRM5 (0.42) | MAPTKCNH2LMNASMN1; SMN2GRM5 | |
| SCHEMBL5479014 | 0.87 | MAPT (0.45) | MAPTLMNASMN1; SMN2GRM5HCRTR1 | |
| SCHEMBL5398780 | 0.87 | KCNH2 (0.45) | MAPTKCNH2LMNASMN1; SMN2GRM5 | |
| SCHEMBL5436283 | 0.86 | HSD11B1 (0.42) | MAPTLMNASMN1; SMN2GRM5HCRTR1 | |
| SCHEMBL5432191 | 0.84 | KCNH2 (0.41) | KCNH2SMN1; SMN2GRM5MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185100-A1 | Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| EP-1716143-A1 | POLYHETEROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20060025414-A1 | Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2006-02-02 | — | — | US | disclosed |
| WO-2005080386-A1 | POLYHETEROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025414-A1 | Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | GRM3, GRM1, GRM4 | MAPT 2055/4885KCNH2 359/4885LMNA 3303/4885 |
| US-20070185100-A1 | Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | GRM3, GRM1, GRM4 | MAPT 1912/4885KCNH2 363/4885LMNA 3378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.