Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL29023295 | 1.00 | TDP1 (0.46) | TDP1MAPK1HSD17B10OR51E2LMNA | |
| Acetic Acid SCHEMBL113972 | 0.93 | MAPK1 (0.44) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Acetic Acid SCHEMBL2772542 | 0.93 | MAPK1 (0.44) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Acetic Acid SCHEMBL3249560 | 0.93 | MAPK1 (0.44) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Acetic Acid SCHEMBL3255637 | 0.93 | MAPK1 (0.44) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Acetic Acid SCHEMBL27775662 | 0.91 | MAPK1 (0.42) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Propylene Glycol SCHEMBL3193750 | 0.88 | TDP1 (0.59) | TDP1MAPK1HSD17B10LMNAMAPT | |
| Propylene Glycol SCHEMBL58534 | 0.85 | TDP1 (0.56) | TDP1MAPK1OR51E2TP53FFAR3 | |
| Propylene Glycol SCHEMBL28261417 | 0.85 | TDP1 (0.56) | TDP1MAPK1OR51E2TP53FFAR3 | |
| Propylene Glycol SCHEMBL28102165 | 0.85 | TDP1 (0.56) | TDP1MAPK1OR51E2TP53FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |