Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 20/20 | 1.00 |
| ▸ | CHRM1 known ✓ | P11229 | 20/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2816171 | 0.99 | CHRM2 (1.00) | CHRM2CHRM1CHRM3 | |
| Bromide SCHEMBL5493208 | 0.95 | CHRM3 (1.00) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2818763 | 0.94 | CHRM3 (1.00) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2835107 | 0.94 | CHRM2 (0.91) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2830933 | 0.93 | CHRM3 (0.88) | CHRM2CHRM1CHRM3 | |
| Bromide SCHEMBL5494567 | 0.92 | CHRM2 (0.86) | CHRM2CHRM1CHRM3 | |
| Bromide SCHEMBL5494569 | 0.92 | CHRM2 (1.00) | CHRM2CHRM1CHRM3 | |
| Bromide SCHEMBL5493206 | 0.92 | CHRM3 (0.85) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2815761 | 0.91 | CHRM2 (0.85) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2815763 | 0.91 | CHRM2 (1.00) | CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208501-B2 | Quinuclidine carbamate derivatives and their use as M3 antagonists | ALMIRALL PRODESFARMA AG (CH) | 2007-04-24 | — | — | US | claimed |
| US-20060094751-A1 | Quinuclidine derivatives and pharmaceutical compositions containing the same | ALMIRALL, S.A. (ES) | 2006-05-04 | — | — | US | disclosed |
| EP-1345937-A1 | QUINUCLIDINE CARBAMATE DERIVATIVES AND THEIR USE AS M3 ANTAGONISTS | Almirall Prodesfarma, S.A. (ES) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051841-A1 | QUINUCLIDINE CARBAMATE DERIVATIVES AND THEIR USE AS M3 ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094751-A1 | Quinuclidine derivatives and pharmaceutical compositions containing the same | CHRM3, CHRM2, CHRM1 | CHRM2 2/4885CHRM1 3/4885CHRM3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.