Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 20/20 | 0.85 |
| ▸ | CHRM2 known ✓ | P08172 | 18/20 | 0.85 |
| ▸ | CHRM1 known ✓ | P11229 | 18/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2818760 | 0.99 | CHRM3 (0.85) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2816829 | 0.94 | CHRM2 (0.77) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2835104 | 0.94 | CHRM2 (0.76) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2816412 | 0.93 | CHRM3 (0.81) | CHRM3CHRM2CHRM1 | |
| Bromide SCHEMBL5486390 | 0.92 | CHRM2 (1.00) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2816171 | 0.91 | CHRM2 (1.00) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2828253 | 0.89 | CHRM2 (0.69) | CHRM3CHRM2CHRM1 | |
| Bromide SCHEMBL5494567 | 0.88 | CHRM2 (0.86) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2828693 | 0.88 | CHRM2 (0.67) | CHRM3CHRM2CHRM1 | |
| Bromide SCHEMBL5493208 | 0.87 | CHRM3 (1.00) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208501-B2 | Quinuclidine carbamate derivatives and their use as M3 antagonists | ALMIRALL PRODESFARMA AG (CH) | 2007-04-24 | — | — | US | claimed |