Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486950 | 1.00 | HRH4 (0.44) | HRH4ENPP1MAOBNTSR1MEN1 | |
| Hydrochloric Acid SCHEMBL5490214 | 0.99 | HRH4 (0.44) | HRH4ENPP1MAOBNTSR1MEN1 | |
| Hydrochloric Acid SCHEMBL5490207 | 0.99 | HRH4 (0.44) | HRH4ENPP1MAOBNTSR1MEN1 | |
| SCHEMBL5485646 | 0.87 | HRH4 (0.42) | HRH4ENPP1MAOBMEN1KMT2A | |
| SCHEMBL5485648 | 0.87 | HRH4 (0.42) | HRH4ENPP1MAOBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5485950 | 0.86 | HRH4 (0.41) | HRH4ENPP1MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL5485955 | 0.86 | HRH4 (0.41) | HRH4ENPP1MEN1KMT2ATP53 | |
| SCHEMBL5405062 | 0.78 | HRH4 (0.57) | HRH4ENPP1MEN1KMT2A | |
| SCHEMBL5412125 | 0.78 | MEN1 (0.60) | HRH4MEN1KMT2A | |
| SCHEMBL5403899 | 0.77 | MEN1 (0.62) | HRH4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205309-B2 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | HRH4 529/4885ENPP1 4421/4885MAOB 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.