Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | NPY4R | P50391 | 2/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | CHRND | Q07001 | 4/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.51 |
| ▸ | CHRNG | P07510 | 1/20 | 0.51 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488639 | 1.00 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4FOLH1 | |
| SCHEMBL5491137 | 0.97 | NPY4R (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4FOLH1 | |
| SCHEMBL5496626 | 0.97 | NPY4R (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4FOLH1 | |
| SCHEMBL14598256 | 0.95 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4FOLH1 | |
| SCHEMBL14598255 | 0.95 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4FOLH1 | |
| SCHEMBL5487472 | 0.95 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4GRIA1 | |
| SCHEMBL5493873 | 0.95 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4GRIA1 | |
| SCHEMBL5489872 | 0.91 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4GRIA1 | |
| SCHEMBL5488598 | 0.91 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4GRIA1 | |
| SCHEMBL14598306 | 0.90 | NPY4R (0.62) | NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | CETP, LDLR, NPC1L1 | CHRNB2 3208/4885CHRNB4 3005/4885CHRNA3 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.