Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503836 | 0.97 | KDM4E (0.39) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL5493470 | 0.88 | EGLN2 (0.45) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL13185348 | 0.86 | KDM4E (0.44) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL14046723 | 0.80 | EGLN2 (0.40) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL5487740 | 0.80 | GRM5 (0.45) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL3505152 | 0.79 | GRM5 (0.41) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL14046725 | 0.78 | KDM4E (0.39) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL995794 | 0.75 | GRM5 (0.54) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| SCHEMBL31172969 | 0.75 | GRM5 (0.54) | GRM5EGLN2KCNH2KDM4EALDH1A1 | |
| 6-(2,2'-Bifuran-5-Yl)Nicotinonitrile SCHEMBL3506917 | 0.75 | MYC (0.42) | GRM5EGLN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249175-A1 | Dicationic compounds which selectively recognize G-quadruplex DNA | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2010-09-30 | — | — | US | disclosed |
| US-7517893-B2 | Bichalcophenes and their prodrugs as antiprotozoal agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-04-14 | — | — | US | disclosed |
| US-7256203-B2 | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256203-B2 | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1792613-A2 | Dicationic compounds which selectively recognize G-quadruplex DNA | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1565458-A2 | DICATIONIC 2,5-DIARYLFURAN AZA-ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040122015-A1 | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents | BOYKIN DAVID W (US) | 2004-06-24 | — | — | US | disclosed |
| WO-2004050018-A2 | DICATIONIC 2,5-DIARYLFURAN AZA-ANALOGS AS ANTI-PROTOZOAN AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249175-A1 | Dicationic compounds which selectively recognize G-quadruplex DNA | DDB1, DNA2, SSBP1 | GRM5 1063/4885EGLN2 4687/4885KCNH2 2913/4885 |
| US-20040122015-A1 | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents | NR0B1, NR2C2, DECR1 | GRM5 1575/4885EGLN2 1489/4885KCNH2 1516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.