Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | NAPEPLD | Q6IQ20 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 5/20 | 0.41 |
| ▸ | CFTR | P13569 | 5/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114523 | 0.81 | KMO (0.52) | KMOPKMCFTRPIK3CA | |
| SCHEMBL425720 | 0.81 | KMO (0.57) | KMOPKMCFTRPIK3CA | |
| SCHEMBL3112249 | 0.81 | KMO (0.49) | KMOPKMCFTRPIK3CAGBA1 | |
| SCHEMBL3110123 | 0.72 | PIK3CA (0.49) | KMOPKMCFTRPIK3CAGBA1 | |
| SCHEMBL16950261 | 0.72 | KMO (0.55) | KMOPKMCFTRPIK3CA | |
| SCHEMBL242170 | 0.72 | KMO (0.56) | KMOPKMPIK3CA | |
| SCHEMBL23299975 | 0.71 | CYP1A2 (0.44) | ATMPIK3C3PIK3CA | |
| SCHEMBL3114998 | 0.71 | KMO (0.56) | KMONAPEPLDPKMPIK3CAGBA1 | |
| SCHEMBL5454003 | 0.71 | KMO (0.49) | KMONAPEPLDPKMPIK3CAGBA1 | |
| SCHEMBL3118342 | 0.71 | KMO (0.52) | KMONAPEPLDPKMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | claimed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | claimed |
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |