Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | HRH2 | P25021 | 4/20 | 0.58 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491850 | 0.91 | HRH3 (0.69) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5287103 | 0.91 | KDM4E (0.64) | KDM4EHRH3MAOBHRH2HRH1 | |
| Methyl Alcohol SCHEMBL4133606 | 0.90 | HRH3 (0.67) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL491570 | 0.89 | HRH3 (0.72) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL7395626 | 0.89 | KDM4E (0.54) | KDM4EHRH3MAOBHRH2HRH1 | |
| SCHEMBL492239 | 0.88 | HRH3 (0.78) | KDM4EHRH3MAOBHRH2HRH1 | |
| SCHEMBL5280536 | 0.85 | HRH3 (0.62) | HRH3CYP2D6 | |
| SCHEMBL491803 | 0.85 | KDM4E (0.92) | KDM4EHRH3MAOBHRH2HRH1 | |
| SCHEMBL5855860 | 0.84 | KDM4E (0.90) | KDM4EHRH3MAOBHRH2HRH1 | |
| SCHEMBL6981478 | 0.84 | KDM4E (0.89) | KDM4EHRH3MAOBHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863487-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103546-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |