Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | CASP3 | P42574 | 2/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.71 |
| ▸ | CCR2 | P41597 | 3/20 | 0.69 |
| ▸ | MAOB | P27338 | 7/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489348 | 0.86 | CCR2 (0.69) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL6180574 | 0.85 | CCR2 (0.68) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL5497567 | 0.84 | CCR2 (0.67) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL5491086 | 0.84 | CCR2 (0.67) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL5491079 | 0.83 | CCR2 (0.65) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL5493182 | 0.83 | CCR2 (0.68) | RAB9ANPC1MEN1KMT2ACCR2 | |
| SCHEMBL6184191 | 0.82 | CCR2 (0.67) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL6180808 | 0.81 | CCR2 (0.62) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL6179692 | 0.81 | CCR2 (0.65) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL5491052 | 0.80 | SMN1; SMN2 (0.60) | RAB9ANPC1MEN1KMT2ACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297696-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2007-11-20 | — | — | US | disclosed |
| US-20050054668-A1 | Antagonists of MCP-1 function and methods of use thereof | LABORDE EDGARDO (US) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054668-A1 | Antagonists of MCP-1 function and methods of use thereof | CCR2, CCR1, CCL2 | RAB9A 3249/4885NPC1 686/4885MEN1 2483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.