Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498972 | 0.96 | TAS1R3 (0.60) | TAS1R3TAS1R1TAS1R2EPHX2RAF1 | |
| SCHEMBL24960538 | 0.90 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL29624981 | 0.84 | TSHR (0.59) | MAPTRORCNOTUMMRGPRX4 | |
| SCHEMBL1920001 | 0.84 | TSHR (0.59) | MAPTRORCNOTUMMRGPRX4 | |
| SCHEMBL22468487 | 0.79 | TAS1R3 (0.60) | TAS1R3TAS1R1TAS1R2NPC1MEN1 | |
| SCHEMBL27680624 | 0.79 | TAS1R3 (0.60) | TAS1R3TAS1R1TAS1R2NPC1MEN1 | |
| SCHEMBL12672349 | 0.79 | HPGD (0.66) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL11627790 | 0.78 | TAS1R3 (0.52) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL531505 | 0.77 | TAS1R3 (0.64) | TAS1R3TAS1R1TAS1R2NPC1MEN1 | |
| SCHEMBL5310506 | 0.76 | MEN1 (0.51) | TAS1R3TAS1R2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |