SCHEMBL5490599

SCHEMBL5490599

Cc1ccc(C)c(CC[Si](Cl)(Cl)Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.57
GAA P10253 1/20 0.41
NPC1 O15118 2/20 0.37
RAB9A P51151 1/20 0.37
POLB P06746 2/20 0.37
HTT P42858 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
TP53 P04637 2/20 0.36
MAPT P10636 1/20 0.36
ALDH1A1 P00352 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
NR3C1 P04150 1/20 0.35
NR3C2 P08235 1/20 0.35
KDM4E B2RXH2 2/20 0.34
HPGD P15428 1/20 0.34
TNF P01375 1/20 0.34
TSHR P16473 1/20 0.34
P2RX7 Q99572 1/20 0.34
KDM4C Q9H3R0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11648936 0.84 PYCR1 (0.39) TAAR1GAANPC1RAB9AHTT
SCHEMBL9491792 0.80 TAAR1 (0.74) TAAR1GAANPC1RAB9APOLB
SCHEMBL13027390 0.77 TAAR1 (0.53) TAAR1GAANPC1RAB9APOLB
SCHEMBL3125997 0.77 TAAR1 (0.63) TAAR1GAANPC1RAB9APOLB
SCHEMBL8713591 0.75 TAAR1 (0.33) TAAR1
SCHEMBL6673171 0.75 TAAR1 (0.54) TAAR1GAAMEN1KMT2AMAPT
SCHEMBL15672331 0.74 TAAR1 (0.50) TAAR1GAANPC1RAB9APOLB
SCHEMBL2045305 0.74 TAAR1 (0.65) TAAR1GAANPC1RAB9APOLB
SCHEMBL698983 0.72 TAAR1 (0.63) TAAR1GAANPC1RAB9APOLB
SCHEMBL8045934 0.72 TAAR1 (0.63) TAAR1GAANPC1RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed
US-5726336-A REACTING A BENZENE COMPOUND WITH A VINYLCHLOROSILANE COMPOUND IN THE PRESENCE OF A LEWIS ACID CATALYST; INTERMEDIATES FOR SILICONE POLYMERS USEFUL AS EMULSIONS, GREASES, ADHESIVES, SEALANTS, COATINGS, IN AUTOMOTIVE AND ENGINEERING FIELDS KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1998-03-10 US disclosed