Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 16/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1729112 | 0.95 | F2R (0.80) | F2RKMT2AKCNH2 | |
| Bromide SCHEMBL1728939 | 0.94 | F2R (0.81) | F2RKMT2AKCNH2 | |
| SCHEMBL14449063 | 0.94 | F2R (0.79) | F2RKMT2AKCNH2 | |
| SCHEMBL1731119 | 0.94 | F2R (0.80) | F2RKMT2AKCNH2 | |
| Bromide SCHEMBL1729586 | 0.94 | F2R (0.82) | F2RKMT2AKCNH2 | |
| SCHEMBL12151694 | 0.93 | F2R (0.81) | F2RKMT2AKCNH2 | |
| Bromide SCHEMBL1730893 | 0.92 | F2R (0.83) | F2RALDH1A1KMT2A | |
| SCHEMBL1730944 | 0.91 | F2R (0.82) | F2RALDH1A1KMT2A | |
| Bromide SCHEMBL1730235 | 0.90 | F2R (0.87) | F2R | |
| Bromide SCHEMBL5486107 | 0.90 | F2R (0.80) | F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | disclosed |