Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | ANPEP | P15144 | 6/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.38 |
| ▸ | LARS1 | Q9P2J5 | 3/20 | 0.38 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368378 | 1.00 | SLC7A5 (0.48) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL4970513 | 0.82 | LARS1 (0.40) | LARS1ALDH1A1MAPK1KDM4E | |
| SCHEMBL8368976 | 0.80 | LARS1 (0.38) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| SCHEMBL4972626 | 0.80 | LARS1 (0.38) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| Leucine SCHEMBL6685428 | 0.77 | SLC7A5 (0.67) | SLC7A5SLC1A3SLC1A2LARS1GRIK1 | |
| Leucine SCHEMBL6685434 | 0.77 | SLC7A5 (0.67) | SLC7A5SLC1A3SLC1A2LARS1GRIK1 | |
| SCHEMBL1001398 | 0.76 | CA12 (0.31) | — | |
| SCHEMBL8365781 | 0.74 | RNPEP (0.35) | ANPEPRNPEP | |
| SCHEMBL8365782 | 0.74 | RNPEP (0.35) | ANPEPRNPEP | |
| SCHEMBL30018651 | 0.74 | SLC7A5 (0.56) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912601-A1 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-05-06 | — | — | EP | claimed |
| WO-1997040066-A1 | SUPPRESSION OF IMMUNE RESPONSE VIA INHIBITION OF CATHEPSIN S | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-10-30 | — | — | WO | claimed |
| US-7238659-B2 | Reducing axon degeneration with proteasome inhibitors | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-20060074028-A1 | Reducing axon degeneration with proteasome inhibitors | CHILDREN'S MEDICAL CENTER CORP | 2006-04-06 | — | — | US | disclosed |
| US-7012063-B2 | Reducing axon degeneration with proteasome inhibitors | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2006-03-14 | — | — | US | disclosed |
| WO-1999058153-A1 | METHODS OF DIAGNOSING AND MODULATING AUTOIMMUNITY | BRIGHAM & WOMEN'S HOSPITAL (US) | 1999-11-18 | — | — | WO | disclosed |