Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155127 | 0.88 | KMO (0.42) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL3121609 | 0.87 | PIK3CA (0.44) | KMOKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL3100542 | 0.87 | KDM4E (0.49) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL4159923 | 0.82 | KMO (0.45) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL4151416 | 0.81 | KMO (0.43) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL11929838 | 0.80 | KMT2A (0.55) | TSHRKMT2APOLBHTTPKM | |
| SCHEMBL3111849 | 0.80 | SYK (0.45) | KDM4ETSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL2073711 | 0.80 | CYP1A2 (0.54) | KDM4ETP53TSHRKMT2AALDH1A1 | |
| SCHEMBL3106043 | 0.80 | KMO (0.46) | KMOKDM4ETP53TSHRMEN1 | |
| SCHEMBL3100746 | 0.79 | TYK2 (0.67) | KMOKDM4EALDH1A1PIK3CAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |