Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.58 |
| ▸ | IL1RN | P18510 | 1/20 | 0.58 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.48 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992761 | 0.80 | CA1 (0.64) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL798074 | 0.80 | CA1 (0.64) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL29653769 | 0.80 | CA1 (0.64) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL1302465 | 0.78 | CA1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6822933 | 0.78 | CA1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL31120812 | 0.78 | CA1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| Potassium SCHEMBL29568431 | 0.78 | CA1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL29011157 | 0.78 | CA1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2371757 | 0.77 | CA1 (0.54) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5450999 | 0.77 | ALDH1A1 (0.63) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056919-A | Substituted sulfonamide derivatives | GRUENENTHAL GMBH | 2011-05-11 | — | — | CN | claimed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | claimed |
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | claimed |
| CN-116964025-A | Halogenated ether and method for producing same, and vinyl ether and method for producing same | 大金工业株式会社 | 2023-10-27 | — | — | CN | disclosed |
| WO-2023077057-A1 | SMALL-MOLECULAR INHIBITORS FOR THE BETA-CATENIN/ B-CELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| CN-109054044-A | A kind of porous crystalline material and its preparation method and application | 中国科学技术大学苏州研究院 | 2018-12-21 | — | — | CN | disclosed |
| EP-3150600-B1 | DIHYDROPYRIMIDO LOOP DERIVATIVE AS HBV INHIBITOR | QILU PHARMACEUTICAL CO LTD (CN) | 2018-06-27 | — | — | EP | disclosed |
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |
| CN-104086540-A | Preparation method for 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS | ANADYS PHARMACEUTICALS INC | 2014-10-08 | — | — | CN | disclosed |
| CN-101677563-B | 5, 6-dihydro-1H-pyridin-2-one compounds | ANADYS PHARMACEUTICALS INC | 2014-06-25 | — | — | CN | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| CN-1078589-C | 4-iodo-2- [ N- (N-alkylaminocarbonyl) -aminosulfonyl ] benzoic acid methyl ester and derivatives thereof, and preparation method thereof | HOECHST SCHERING AGREVO GMBH (DE) | 2002-01-30 | — | — | CN | disclosed |
| CN-1223638-A | 4-iodo-2- [ N- (N-alkylaminocarbonyl) -aminosulfonyl ] benzoic acid methyl ester and derivatives thereof, and preparation method thereof | HOECHST SCHERING AGREVO GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0644188-A1 | Process for the preparation of sulfur derivatives of imidazole and intermediates obtained | ROUSSEL UCLAF (FR) | 1995-03-22 | — | — | EP | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |