Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699203 | 0.92 | EGFR (0.54) | EGFRERBB2KCNH2FLT1EPHA2 | |
| SCHEMBL28756455 | 0.88 | ERBB2 (0.62) | EGFRERBB2KCNH2 | |
| SCHEMBL3816930 | 0.88 | ERBB2 (0.62) | EGFRERBB2KCNH2 | |
| SCHEMBL5699179 | 0.86 | ERBB2 (0.64) | EGFRERBB2KCNH2 | |
| SCHEMBL4483658 | 0.85 | ERBB2 (0.53) | EGFRERBB2KCNH2 | |
| SCHEMBL4473685 | 0.84 | ERBB2 (0.52) | EGFRERBB2KCNH2 | |
| SCHEMBL3807571 | 0.83 | EGFR (0.54) | EGFRERBB2KCNH2FLT1EPHA2 | |
| SCHEMBL4480637 | 0.83 | ERBB2 (0.67) | EGFRERBB2KCNH2 | |
| SCHEMBL3810196 | 0.83 | EGFR (0.54) | EGFRERBB2KCNH2FLT1EPHA2 | |
| SCHEMBL5493875 | 0.82 | ERBB2 (0.53) | EGFRERBB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511491-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | claimed |