Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 19/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481289 | 0.85 | ERBB2 (0.56) | ERBB2EGFRKCNH2 | |
| SCHEMBL4480709 | 0.84 | ERBB2 (0.67) | ERBB2EGFRKCNH2 | |
| SCHEMBL5490957 | 0.82 | EGFR (0.55) | ERBB2EGFRKCNH2 | |
| SCHEMBL4483658 | 0.81 | ERBB2 (0.53) | ERBB2EGFRKCNH2 | |
| SCHEMBL5699203 | 0.81 | EGFR (0.54) | ERBB2EGFRKCNH2 | |
| SCHEMBL4483967 | 0.81 | ERBB2 (0.55) | ERBB2EGFRKCNH2 | |
| SCHEMBL4472955 | 0.81 | EGFR (0.51) | ERBB2EGFRKCNH2 | |
| SCHEMBL4473685 | 0.80 | ERBB2 (0.52) | ERBB2EGFRKCNH2 | |
| SCHEMBL3807571 | 0.80 | EGFR (0.54) | ERBB2EGFRKCNH2 | |
| SCHEMBL3816930 | 0.79 | ERBB2 (0.62) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511491-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | claimed |