⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1788406 | 1.00 | — | — | |
| SCHEMBL1791184 | 0.71 | — | — | |
| SCHEMBL1791186 | 0.71 | — | — | |
| SCHEMBL169861 | 0.70 | — | — | |
| SCHEMBL4665561 | 0.61 | — | — | |
| SCHEMBL7366683 | 0.58 | — | — | |
| SCHEMBL187115 | 0.58 | — | — | |
| SCHEMBL7055034 | 0.58 | — | — | |
| SCHEMBL4933840 | 0.58 | — | — | |
| SCHEMBL146249 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898571-B1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2003-11-19 | — | — | EP | claimed |
| US-6545014-B2 | Glaucoma; adjusting concentration of nitric oxide; hypotensive, antispasmodic, antiischemic, cardiotonic agents; bronchodilators; urogentital disorders; agonists, antagonists for endothelin receptors | TEXAS BIOTECHNOLOGY CORPORATION | 2003-04-08 | — | — | US | claimed |
| US-6376523-B1 | HYPOTENSIVE AGENTS; ANTIINFLAMMATORY AGENTS; ENDOGENOUS VASOCONSTRUCTION PEPTIDE | TEXAS BIOTECHNOLOGY CORPORATION | 2002-04-23 | — | — | US | claimed |
| US-20020028829-A1 | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. | 2002-03-07 | — | — | US | claimed |
| US-6329387-B2 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENTS, VISION DEFECTS | TEXAS BIOTECHNOLOGY CORPORATION. | 2001-12-11 | — | — | US | claimed |
| US-20010036958-A1 | Benzenesulfonamides and the use thereof to modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS, INC. | 2001-11-01 | — | — | US | claimed |
| US-20010014684-A1 | THIENO-PYRIDINE SULFONAMIDES DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC. | 2001-08-16 | — | — | US | claimed |
| EP-1069114-A2 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-01-17 | — | — | EP | claimed |
| US-6030991-A | ADJUSTING THE BINDING OF AN ENDOTHELIN PEPTIDE TO ENDOTHELIN A OR, PARTICULARLY, ENDOTHELIN B RECEPTORS, I.E. INHIBITING OR STIMULATING; ANTIINFLAMMATORY AGENT; ASTHMA; KIDNEYS; GASTROINTESTINAL, CARDIOASCULAR DISORDERS; HYPOTENSIVE AGENTS | TEXAS BIOTECHNOLOGY CORP. (US) | 2000-02-29 | — | — | US | claimed |
| US-6013655-A | HYPOTENSIVE AGENTS; RESPIRATORY SYSTEM DIISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-01-11 | — | — | US | claimed |
| US-5958905-A | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-09-28 | — | — | US | claimed |
| EP-0898571-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0889894-A1 | PHOSPHORAMIDATES AND PHOSPHINIC AMIDES, THEIR USE TO MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-01-13 | — | — | EP | claimed |
| EP-0870764-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-10-14 | — | — | EP | claimed |
| WO-1997039000-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-10-23 | — | — | WO | claimed |
| WO-1997035864-A1 | PHOSPHORAMIDATES AND PHOSPHINIC AMIDES, THEIR USE TO MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-10-02 | — | — | WO | claimed |
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | claimed |
| US-7179582-B2 | Radical polymerizable composition and lithographic printing plate precursor using the same | FUJI PHOTO FILM CO., LTD. (JP) | 2007-02-20 | — | — | US | disclosed |
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | disclosed |