Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15272805 | 0.90 | ABHD6 (0.41) | NOTUMABHD6ROCK1MEN1KMT2A | |
| SCHEMBL4554909 | 0.88 | ROCK1 (0.41) | NOTUMABHD6ROCK1HRH3 | |
| SCHEMBL14677886 | 0.86 | ABHD6 (0.44) | NOTUMABHD6ROCK1 | |
| SCHEMBL587257 | 0.84 | ESR2 (0.46) | ABHD6TMEM97SIGMAR1MAPT | |
| SCHEMBL31428727 | 0.80 | NOTUM (0.50) | NOTUMABHD6ROCK1MEN1KMT2A | |
| SCHEMBL4518196 | 0.80 | NOTUM (0.50) | NOTUMABHD6ROCK1MEN1KMT2A | |
| SCHEMBL18524347 | 0.79 | PTGDR2 (0.39) | ROCK1PTGDR2HTR5A | |
| SCHEMBL28849175 | 0.79 | ROCK1 (0.33) | ROCK1 | |
| SCHEMBL19949283 | 0.78 | ABHD6 (0.37) | NOTUMABHD6KMT2ANPC1KDM4E | |
| SCHEMBL16101023 | 0.77 | ROCK1 (0.39) | ABHD6ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831199-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065215-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |