Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494957 | 0.93 | HPGD (0.51) | HPGD | |
| SCHEMBL5500252 | 0.81 | HPGD (0.40) | HPGD | |
| SCHEMBL5492379 | 0.81 | PTPN1 (0.52) | — | |
| SCHEMBL5496771 | 0.81 | PTPN1 (0.52) | — | |
| SCHEMBL18554061 | 0.80 | REN (0.64) | REN | |
| SCHEMBL20474604 | 0.80 | REN (0.64) | REN | |
| SCHEMBL5491032 | 0.80 | FOLH1 (0.50) | — | |
| SCHEMBL5495776 | 0.80 | FOLH1 (0.50) | — | |
| SCHEMBL18375234 | 0.79 | ALPI (0.59) | — | |
| SCHEMBL11254327 | 0.79 | ALPI (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | CETP, LDLR, NPC1L1 | TPH1 4466/4885REN 1943/4885HPGD 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.