SCHEMBL5492928

SCHEMBL5492928

O=C(O)C1(NS(=O)(=O)c2ccc(OCc3ccc(Cl)cc3Cl)cc2)C[C@H]1c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 9/20 0.64
NR4A2 P43354 2/20 0.47
ADAMTS4 O75173 4/20 0.47
MMP13 P45452 4/20 0.47
MMP1 P03956 3/20 0.47
ADAM17 P78536 2/20 0.47
ADAMTS7 Q9UKP4 1/20 0.46
MMP2 P08253 3/20 0.46
MMP14 P50281 2/20 0.46
MMP3 P08254 1/20 0.46
MMP9 P14780 1/20 0.46
MMP12 P39900 1/20 0.46
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
NCOA1 Q15788 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NCOA3 Q9Y6Q9 1/20 0.45
S1PR1 P21453 1/20 0.45
LTK P29376 1/20 0.45
TAOK1 Q7L7X3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2766952 1.00 ADAMTS5 (0.64) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL2765689 1.00 ADAMTS5 (0.64) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL2764703 0.92 ADAMTS5 (0.53) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL2764706 0.92 ADAMTS5 (0.53) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL2764823 0.81 ADAMTS5 (0.48) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL13398535 0.81 ADAMTS5 (0.48) ADAMTS5NR4A2ADAMTS4MMP13MMP1
SCHEMBL13991450 0.81 ADAMTS5 (0.78) ADAMTS5
SCHEMBL2764374 0.79 ADAMTS5 (1.00) ADAMTS5MMP2
SCHEMBL2764561 0.79 ADAMTS5 (1.00) ADAMTS5MMP2
SCHEMBL2764668 0.79 ADAMTS5 (1.00) ADAMTS5MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007516982-A 2007-06-28 JP claimed
EP-1694410-A2 CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF Japan Tobacco, Inc. (JP) 2006-08-30 EP claimed
WO-2005058884-A2 CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2005-06-30 WO claimed
EP-1694410-A2 CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF Japan Tobacco, Inc. (JP) 2006-08-30 EP disclosed
WO-2005058884-A2 CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2005-06-30 WO disclosed