SCHEMBL5492963

SCHEMBL5492963

CCCCCC=CCC=CCC=CCC#CCCCC(=O)O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 7/20 0.69
PPARD Q03181 6/20 0.69
PPARA Q07869 6/20 0.69
ALDH1A1 P00352 5/20 0.69
F7 P08709 5/20 0.69
F3 P13726 5/20 0.69
FABP4 P15090 4/20 0.69
HSD17B10 Q99714 4/20 0.69
FFAR1 O14842 3/20 0.69
LMNA P02545 3/20 0.69
CYP19A1 P11511 3/20 0.69
ALOX15 P16050 3/20 0.69
NR4A2 P43354 3/20 0.69
PTGS1 P23219 3/20 0.69
MAPT P10636 3/20 0.69
BLM P54132 3/20 0.69
L3MBTL1 Q9Y468 2/20 0.69
KDM4E B2RXH2 2/20 0.69
CYP3A4 P08684 2/20 0.69
HPGD P15428 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5492958 1.00 PPARG (0.69) PPARGPPARDPPARAALDH1A1F7
SCHEMBL31265312 1.00 PPARG (0.69) PPARGPPARDPPARAALDH1A1F7
SCHEMBL5492961 1.00 PPARG (0.69) PPARGPPARDPPARAALDH1A1F7
SCHEMBL10810022 0.96 ALDH1A1 (0.63) PPARGPPARDPPARAALDH1A1F7
SCHEMBL10810016 0.96 ALDH1A1 (0.63) PPARGPPARDPPARAALDH1A1F7
SCHEMBL7594655 0.96 PPARG (0.71) PPARGPPARDPPARAALDH1A1F7
SCHEMBL7589866 0.96 PPARG (0.71) PPARGPPARDPPARAALDH1A1F7
SCHEMBL10919688 0.95 PPARG (0.64) PPARGPPARDPPARAALDH1A1F7
SCHEMBL10918369 0.94 PTPN7 (0.67) PPARGPPARDPPARAF7F3
SCHEMBL10809493 0.90 RECQL (0.69) PPARGPPARDPPARAALDH1A1F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5702697-A FREE RADICAL CELL DAMAGE CHIRON CORPORATION (US) 1997-12-30 US claimed
EP-0269017-B1 THERAPEUTIC COMBINATION OF FREE-RADICAL SCAVENGER OR METABOLIC INHIBITOR AND BIOLOGICALLY ACTIVE PROTEIN CETUS ONCOLOGY CORPORATION (US) 1992-07-29 EP claimed
EP-0269017-A2 Therapeutic combination of free-radical scavenger or metabolic inhibitor and biologically active protein CETUS ONCOLOGY CORPORATION (US) 1988-06-01 EP claimed
EP-1100507-B1 USE OF A COMBINATION COMPRISING A PRECURSOR OF URIC ACID AND ANTIOXIDANT FOR THE TREATMENT OF NEURODEGENERATIVE DESEASES SACKS MEIR S (US) 2007-01-24 EP disclosed
US-5702697-A FREE RADICAL CELL DAMAGE CHIRON CORPORATION (US) 1997-12-30 US disclosed
US-5667776-A ANTICARCINOGENIC AGENTS, TREATMENT OF INFECTIOUS DISEASES AND DAMAGE FROM RADIATION OR CHEMOTHERAPY CHIRON CORPORATION (US) 1997-09-16 US disclosed
US-5508031-A Method for treating biological damage using a free-radial scavenger and interleukin-2 CETUS ONCOLOGY CORPORATION (US) 1996-04-16 US disclosed
EP-0269017-B1 THERAPEUTIC COMBINATION OF FREE-RADICAL SCAVENGER OR METABOLIC INHIBITOR AND BIOLOGICALLY ACTIVE PROTEIN CETUS ONCOLOGY CORPORATION (US) 1992-07-29 EP disclosed
US-4985241-A URIC ACID, BUTHIONINE SULPHOXIMINE, VITAMIN C CETUS CORPORATION (US) 1991-01-15 US disclosed
EP-0269017-A2 Therapeutic combination of free-radical scavenger or metabolic inhibitor and biologically active protein CETUS ONCOLOGY CORPORATION (US) 1988-06-01 EP disclosed