Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL5507642 | 0.77 | ABL1 (0.47) | ABL1AAK1CYP11B1CYP11B2BRAF | |
| SCHEMBL5501140 | 0.77 | LCK (0.61) | ABL1AAK1BRAFLCKKDR | |
| SCHEMBL4733367 | 0.76 | LCK (0.70) | ABL1CYP11B1CYP11B2BRAFLCK | |
| SCHEMBL30494215 | 0.76 | LCK (0.70) | ABL1CYP11B1CYP11B2BRAFLCK | |
| SCHEMBL5493001 | 0.73 | ABL1 (0.46) | ABL1CYP11B1CYP11B2BRAFLCK | |
| SCHEMBL5496775 | 0.70 | ABL1 (0.54) | ABL1CYP11B1CYP11B2BRAFLCK | |
| SCHEMBL9938086 | 0.69 | ABL1 (1.00) | ABL1CYP11B1CYP11B2 | |
| Ammonia Solution, Strong SCHEMBL5496907 | 0.69 | ABL1 (0.62) | ABL1CYP11B1CYP11B2BRAFLCK | |
| Hydrazine SCHEMBL21402121 | 0.69 | ABL1 (0.46) | ABL1CYP11B1CYP11B2BRAFLCK | |
| SCHEMBL18899879 | 0.69 | ABL1 (0.74) | ABL1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |