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Sugi Predict / Compounds / SCHEMBL5493300

SCHEMBL5493300

SCHEMBL5493300

Cc1c(S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 19/20 0.63
▸ CCR1 P32246 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4131190 0.91 ELANE (0.68) ELANE
SCHEMBL5496689 0.88 ELANE (0.62) ELANE
SCHEMBL5490151 0.88 ELANE (0.62) ELANE
SCHEMBL4124431 0.86 ELANE (0.72) ELANE
SCHEMBL4139009 0.86 ELANE (0.77) ELANE
SCHEMBL4131024 0.85 ELANE (0.63) ELANE
SCHEMBL4028533 0.85 ELANE (0.72) ELANE
SCHEMBL31315019 0.85 ELANE (0.72) ELANE
SCHEMBL4143355 0.84 ELANE (0.75) ELANE
SCHEMBL4131007 0.84 ELANE (0.63) ELANECCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1861371-A1 NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. AstraZeneca AB (SE) 2007-12-05 — — EP disclosed
WO-2006098684-A1 NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. ASTRAZENECA AB (SE) 2006-09-21 — — WO disclosed