Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391759 | 0.92 | NR4A2 (0.49) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL29874714 | 0.92 | NR4A2 (0.49) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL30017691 | 0.87 | NR4A2 (0.53) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL155514 | 0.87 | NR4A2 (0.53) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL16050286 | 0.81 | ALDH1A1 (0.50) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL152998 | 0.81 | NR4A2 (0.50) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL29828567 | 0.81 | NR4A2 (0.50) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL16056048 | 0.80 | NR4A2 (0.47) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL550390 | 0.80 | SMN1; SMN2 (0.51) | ALDH1A1GAASMN1; SMN2L3MBTL1HSD17B10 | |
| SCHEMBL7662781 | 0.80 | NR4A2 (0.49) | NR4A2ALDH1A1GAASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737854-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100351-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |