Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.47 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.46 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.44 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786176 | 0.82 | MAPT (0.59) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL16038329 | 0.81 | CHRM5 (0.56) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| SCHEMBL3786181 | 0.81 | CHRM1 (0.52) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Bromide SCHEMBL1161079 | 0.80 | CHRM1 (0.55) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Bromide SCHEMBL1161318 | 0.79 | ACHE (0.49) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Methacrylic Acid SCHEMBL2511701 | 0.77 | CHRM5 (0.57) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Methacrylic Acid SCHEMBL21931217 | 0.77 | CHRM5 (0.57) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| SCHEMBL8733322 | 0.77 | CHRM5 (0.55) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| SCHEMBL3789468 | 0.76 | CHRM5 (0.59) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 | |
| Methacrylic Acid SCHEMBL16444097 | 0.76 | CHRM5 (0.55) | SMN1; SMN2LMNAAPEX1CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7213934-B2 | Light emitting medium and illumination system | ZARIAN JAMES ROUBEN | 2007-05-08 | — | — | US | disclosed |
| US-20060098422-A1 | Light emitting medium and illumination system | ZARIAN JAMES R | 2006-05-11 | — | — | US | disclosed |