Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493751 | 1.00 | MAPT (0.42) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL30083330 | 0.83 | MAPT (0.42) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL396236 | 0.83 | MAPT (0.42) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL396237 | 0.83 | MAPT (0.42) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL21907038 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL395183 | 0.78 | MAPT (0.49) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL14403722 | 0.72 | ALDH1A1 (0.41) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL9317168 | 0.70 | NSD2 (0.43) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL22391943 | 0.69 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL297058 | 0.68 | ALDH1A1 (0.51) | MAPTALDH1A1LMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |