Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.72 |
| ▸ | AKT2 | P31751 | 12/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501778 | 0.85 | AKT1 (0.64) | AKT1AKT2LMNATSHRKCNH2 | |
| SCHEMBL3891901 | 0.84 | AKT1 (1.00) | AKT1AKT2LMNATSHRAKT3 | |
| SCHEMBL1940085 | 0.83 | AKT1 (0.67) | AKT1AKT2LMNATSHRPPARA | |
| SCHEMBL27711061 | 0.79 | AKT1 (0.60) | AKT1AKT2LMNATSHRPPARA | |
| SCHEMBL5501239 | 0.75 | AKT1 (0.68) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL1501692 | 0.74 | KCNH2 (0.64) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5501008 | 0.74 | AKT1 (0.69) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5498279 | 0.74 | AKT1 (0.69) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5501005 | 0.74 | AKT1 (0.57) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5499246 | 0.74 | AKT1 (0.75) | AKT1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827436-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006065601-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | claimed |