Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.68 |
| ▸ | AKT2 | P31751 | 17/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501556 | 0.83 | KCNH2 (0.71) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5498279 | 0.80 | AKT1 (0.69) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5501008 | 0.79 | AKT1 (0.69) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5499246 | 0.78 | AKT1 (0.75) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5498925 | 0.78 | AKT1 (0.70) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5493914 | 0.75 | AKT1 (0.72) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5497263 | 0.72 | AKT1 (0.75) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL5501005 | 0.71 | AKT1 (0.57) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL8484497 | 0.70 | DRD4 (1.00) | DRD2DRD4DRD3KCNH2 | |
| SCHEMBL2281520 | 0.69 | AKT1 (0.61) | AKT1AKT2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827436-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006065601-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | claimed |