Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 4/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491016 | 1.00 | LCK (0.56) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL41115 | 0.86 | LCK (0.53) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL28298101 | 0.84 | LCK (0.69) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL24457803 | 0.82 | LCK (0.47) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL41400 | 0.82 | LCK (0.53) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5494034 | 0.82 | LCK (0.56) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5489139 | 0.82 | LCK (0.72) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5492624 | 0.82 | LCK (0.59) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5492816 | 0.79 | LCK (0.72) | LCKKDRJAK3MAPK14DHFR | |
| SCHEMBL5494272 | 0.79 | LCK (0.58) | LCKKDRJAK3MAPK14DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |