Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.94 |
| ▸ | F10 | P00742 | 1/20 | 0.94 |
| ▸ | F12 | P00748 | 1/20 | 0.94 |
| ▸ | F7 | P08709 | 1/20 | 0.94 |
| ▸ | F3 | P13726 | 1/20 | 0.94 |
| ▸ | PKM | P14618 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 2/20 | 0.89 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.84 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.84 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.84 |
| ▸ | C1S | P09871 | 2/20 | 0.84 |
| ▸ | RECQL | P46063 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | WDR5 | P61964 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PLAU | P00749 | 2/20 | 0.55 |
| ▸ | MASP2 | O00187 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamidine SCHEMBL27781057 | 0.97 | F2 (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL23067876 | 0.97 | F2 (1.00) | F2F10F12F7F3 | |
| SCHEMBL18557033 | 0.97 | F2 (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL9207 | 0.97 | — | — | |
| Benzamidine SCHEMBL31530552 | 0.94 | F2 (0.94) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL29191426 | 0.94 | F2 (0.94) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL6861235 | 0.94 | BLM (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL23235801 | 0.94 | BLM (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL2877747 | 0.94 | F2 (0.94) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL7103811 | 0.94 | F2 (0.94) | F2F10F12F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596933-B | Herbicidal pyrimidone derivatives | DU PONT | 2014-09-17 | — | — | CN | disclosed |
| CN-102596933-A | Herbicidal pyrimidone derivatives | DU PONT | 2012-07-18 | — | — | CN | disclosed |
| US-7309483-B2 | Method of treatment using Tie2 ligand2 | REGENERON PHARMACEUTICALS, INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-7063840-B2 | TIE-2 ligands, methods of making and uses thereof | REGENERON PHARMACEUTICALS, INC. (US) | 2006-06-20 | — | — | US | disclosed |
| US-7063965-B2 | Nucleic acid encoding TIE-2 ligand | REGENERON PHARMACEUTICALS, INC. (US) | 2006-06-20 | — | — | US | disclosed |
| US-7045302-B2 | Expressed ligand-vascular intercellular signaling molecule | REGENERON PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20050186665-A1 | Expressed ligand - vascular intercellular signaling molecule | REGENERON PHARMACEUTICALS, INC. | 2005-08-25 | — | — | US | disclosed |
| US-20050175617-A1 | Tie-2 ligands, methods of making and uses thereof | REGENERON PHARMACEUTICALS, INC. | 2005-08-11 | — | — | US | disclosed |
| US-20050106099-A1 | Expressed ligand-vascular intercellular signaling molecule | REGENERON PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
| US-20050100906-A1 | TIE-2 ligands, methods of making and uses thereof | DAVIS SAMUEL (US) | 2005-05-12 | — | — | US | disclosed |
| WO-1998005779-A1 | MODIFIED TIE-2-RECEPTOR LIGANDS | REGENERON PHARMACEUTICALS, INC. (US) | 1998-02-12 | — | — | WO | disclosed |
| EP-0821728-A1 | TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1997048804-A2 | TIE-2 RECEPTOR LIGANDS (TIE LIGAND-3; TIE LIGAND-4) AND THEIR USES | REGENERON PHARMACEUTICALS, INC. (US) | 1997-12-24 | — | — | WO | disclosed |
| EP-0784683-A1 | TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5650490-A | Tie-2 ligand 2 | REGENERON PHARMACEUTICALS, INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5643755-A | Nucleic acid encoding tie-2 ligand | REGENERON PHARMACEUTICALS INC. (US) | 1997-07-01 | — | — | US | disclosed |
| WO-1996031598-A1 | TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 1996-10-10 | — | — | WO | disclosed |
| WO-1996011269-A9 | TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF | — | 1996-06-06 | — | — | WO | disclosed |
| US-5521073-A | TIE-2 ligand, and method of making | REGENERON PHARMACEUTICALS, INC. (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1996011269-A2 | TIE-2 LIGANDS, METHODS OF MAKING AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |