Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perflexane SCHEMBL8841162 | 0.94 | LMNA (0.57) | LMNATHRBCA2CA1MMP1 | |
| Perflubutane SCHEMBL9051673 | 0.94 | LMNA (0.54) | LMNATHRBCA2CA1MMP1 | |
| Perflubutane SCHEMBL111514 | 0.94 | LMNA (0.54) | LMNATHRBCA2CA1MMP1 | |
| Perflutren SCHEMBL1446805 | 0.94 | LMNA (0.43) | LMNATHRBCA2 | |
| Perflutren SCHEMBL34348 | 0.94 | LMNA (0.43) | LMNATHRBCA2 | |
| SCHEMBL1707474 | 0.88 | LMNA (0.61) | LMNATHRBCA2CA1MMP1 | |
| Perflutren SCHEMBL8970515 | 0.88 | LMNA (0.40) | LMNATHRB | |
| Perflexane SCHEMBL20769778 | 0.88 | LMNA (0.61) | LMNATHRBCA2CA1MMP1 | |
| Perflubutane SCHEMBL6229729 | 0.88 | LMNA (0.50) | LMNATHRBCA2CA1MMP1 | |
| SCHEMBL1779065 | 0.88 | LMNA (0.61) | LMNATHRBCA2CA1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7198949-B2 | Compositions and methods for altering the biodistribution of biological agents | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040057946-A1 | Compositions and methods for altering the biodistribution of biological agents | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2004-03-25 | — | — | US | disclosed |