Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | TPMT | P51580 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071184 | 0.88 | SMN1; SMN2 (0.70) | ACLYSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL5364834 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1ALDH1A1KMT2ACA12 | |
| SCHEMBL15662236 | 0.84 | TSHR (0.56) | SMN1; SMN2MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL7039348 | 0.82 | ALDH1A1 (0.50) | ACLYSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL567311 | 0.82 | NEU3 (0.63) | SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL29791247 | 0.82 | NEU3 (0.63) | SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL3247653 | 0.81 | ALDH1A1 (0.61) | SMN1; SMN2MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL14799282 | 0.81 | HPGD (0.59) | SMN1; SMN2MEN1ALDH1A1KMT2ACA1 | |
| SCHEMBL2803800 | 0.80 | MYC (0.50) | SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL2217939 | 0.80 | CA12 (0.65) | ACLYMEN1ALDH1A1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1984883-B | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies | PROTEOTECH INC | 2012-03-21 | — | — | CN | disclosed |
| CN-1984883-A | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies | PROTEOTECH INC (US) | 2007-06-20 | — | — | CN | disclosed |
| EP-1751097-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | Proteotech, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113489-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH, INC. (US) | 2005-12-01 | — | — | WO | disclosed |