Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | BCL2L11 | O43521 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549550 | 1.00 | HSD11B1 (0.45) | HSD11B1AKR1C3CNR1OPRM1ADAMTS5 | |
| SCHEMBL549507 | 1.00 | HSD11B1 (0.45) | HSD11B1AKR1C3CNR1OPRM1ADAMTS5 | |
| SCHEMBL549551 | 1.00 | HSD11B1 (0.45) | HSD11B1AKR1C3CNR1OPRM1ADAMTS5 | |
| SCHEMBL2699389 | 1.00 | HSD11B1 (0.45) | HSD11B1AKR1C3CNR1OPRM1ADAMTS5 | |
| SCHEMBL2699387 | 1.00 | HSD11B1 (0.45) | HSD11B1AKR1C3CNR1OPRM1ADAMTS5 | |
| SCHEMBL550832 | 0.88 | HSD11B1 (0.36) | HSD11B1OPRM1ADAMTS5 | |
| SCHEMBL2700964 | 0.88 | HSD11B1 (0.36) | HSD11B1OPRM1ADAMTS5 | |
| SCHEMBL550833 | 0.88 | HSD11B1 (0.36) | HSD11B1OPRM1ADAMTS5 | |
| SCHEMBL2700965 | 0.88 | HSD11B1 (0.36) | HSD11B1OPRM1ADAMTS5 | |
| SCHEMBL550559 | 0.88 | HSD11B1 (0.36) | HSD11B1OPRM1ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |