Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PLTP | P55058 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330267 | 0.81 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL330526 | 0.81 | TMPRSS4 (0.42) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL331811 | 0.80 | MAPT (0.38) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL331528 | 0.78 | MAPT (0.39) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL330479 | 0.70 | RAB9A (0.67) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL330465 | 0.70 | TMPRSS4 (0.42) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL330259 | 0.70 | KMT2A (0.60) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL330478 | 0.69 | TMPRSS4 (0.43) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL330283 | 0.69 | GPER1 (0.44) | MAPTSMN1; SMN2TMPRSS4GAAKMT2A | |
| SCHEMBL330992 | 0.68 | XIAP (0.56) | MAPTSMN1; SMN2KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847263-A2 | Inhibitors against the production and release of inflammatory cytokines | Institute of Medicinal Molecular Design, Inc. (JP) | 2007-10-24 | — | — | EP | disclosed |
| EP-1844766-A2 | Inhibitors against the production and release of inflammatory cytokines | Institute of Medicinal Molecular Design, Inc. (JP) | 2007-10-17 | — | — | EP | disclosed |