Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496363 | 0.78 | LCK (0.53) | BRAFLCKKDRMAPK14MAPK9 | |
| SCHEMBL5496353 | 0.76 | LCK (0.53) | BRAFLCKKDRMAPK14MAPK9 | |
| SCHEMBL5489346 | 0.76 | BRAF (0.49) | BRAFLCKKDRMAPK14MAPK9 | |
| SCHEMBL5499069 | 0.69 | BRAF (0.49) | BRAFLCKRIPK1RIPK3MAP4K1 | |
| SCHEMBL5495562 | 0.67 | BRAF (0.48) | BRAFMAPK9MAP4K1ABL1 | |
| SCHEMBL14568512 | 0.67 | IRAK4 (0.55) | BRAFLCKKDRMAPK14MAP4K1 | |
| SCHEMBL5500764 | 0.67 | IRAK4 (0.55) | BRAFLCKKDRMAPK14MAP4K1 | |
| SCHEMBL5498511 | 0.67 | RIPK2 (0.52) | BRAFLCKKDRMAPK14MAPK10 | |
| SCHEMBL5497234 | 0.67 | RIPK2 (0.52) | BRAFLCKKDRMAPK14MAPK10 | |
| SCHEMBL5502267 | 0.66 | RIPK1 (0.70) | LCKKDRMAPK14MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |