Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | KIFC1 | Q9BW19 | 4/20 | 0.47 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.45 |
| ▸ | CHRNG | P07510 | 2/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.45 |
| ▸ | CHRND | Q07001 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496941 | 0.82 | CHRNB2 (0.46) | L3MBTL1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5492131 | 0.82 | CHRNB2 (0.46) | L3MBTL1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5494652 | 0.80 | TACR2 (0.53) | AVPR1AKIFC1TACR2L3MBTL1AVPR1B | |
| SCHEMBL5491140 | 0.79 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4CTSS | |
| SCHEMBL5494078 | 0.79 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4CTSS | |
| SCHEMBL5491193 | 0.79 | TACR2 (0.55) | AVPR1AKIFC1TACR2L3MBTL1AVPR1B | |
| SCHEMBL6407898 | 0.78 | F7 (0.55) | CTSS | |
| SCHEMBL5495303 | 0.77 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4CTSS | |
| SCHEMBL5494080 | 0.74 | TACR2 (0.55) | AVPR1ATACR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6575335 | 0.73 | PTPN1 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | SIRCAR JAGADISH C | 2007-01-04 | — | — | US | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004644-A1 | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia | CETP, LDLR, NPC1L1 | AVPR1A 2997/4885KIFC1 2520/4885TACR2 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.