Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | JAK1 | P23458 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24782968 | 0.76 | EGFR (0.68) | AREGFRNOTUMIMPDH2BRAF | |
| SCHEMBL3953384 | 0.76 | KDR (0.45) | JAK2JAK1KDRFLT1AR | |
| SCHEMBL27936888 | 0.76 | AR (0.62) | AREGFRNPC1RAB9ANOTUM | |
| SCHEMBL28434934 | 0.76 | NOTUM (0.58) | AREGFRNOTUMIMPDH2 | |
| SCHEMBL5628546 | 0.75 | CDC25B (0.50) | AREGFRNOTUM | |
| SCHEMBL5629016 | 0.74 | MAPK8 (0.55) | JAK2KDRFLT1AREGFR | |
| SCHEMBL28451772 | 0.74 | NOTUM (0.56) | KDRAREGFRNPC1RAB9A | |
| SCHEMBL5495693 | 0.74 | MKNK1 (0.46) | AREGFRBRAF | |
| SCHEMBL12386087 | 0.73 | MEN1 (0.59) | JAK2JAK1NPC1RAB9A | |
| SCHEMBL29985822 | 0.72 | EGFR (0.61) | AREGFRNPC1RAB9ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |