Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.49 |
| ▸ | PIM1 | P11309 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.49 |
| ▸ | MELK | Q14680 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.49 |
| ▸ | PAK4 | O96013 | 3/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5628546 | 0.83 | CDC25B (0.50) | EGFRKDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL2485382 | 0.79 | EGFR (0.63) | EGFRMAPK1PTGS1PTGS2KDM4E | |
| SCHEMBL10144151 | 0.76 | FABP4 (0.62) | TAS2R14FABP4CTSVCTSLFTO | |
| SCHEMBL29985822 | 0.75 | EGFR (0.61) | EGFRMEN1NPC1MAPTKMT2A | |
| SCHEMBL5495689 | 0.74 | JAK2 (0.63) | EGFRJAK2ABL1CSF1RIGF1R | |
| SCHEMBL27881434 | 0.74 | EGFR (0.59) | EGFRMEN1NPC1MAPTKMT2A | |
| SCHEMBL18109767 | 0.73 | FABP4 (0.85) | DAPK3PIM1CDK2FLT3GSK3B | |
| SCHEMBL5425226 | 0.73 | ROCK2 (0.74) | MAPK8EGFRDAPK3PIM1CDK2 | |
| SCHEMBL28133218 | 0.72 | FABP4 (0.75) | TAS2R14FABP4CTSVCTSLFTO | |
| SCHEMBL29972584 | 0.72 | AR (0.51) | EGFRROCK2KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307088-B2 | Substituted anthranilic amide derivatives and methods of use | AMGEN INC. (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1519921-A2 | SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2005-04-06 | — | — | EP | disclosed |
| US-20040087568-A1 | Substituted anthranilic amide derivatives and methods of use | AMGEN INC. | 2004-05-06 | — | — | US | disclosed |
| WO-2004005279-A2 | SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087568-A1 | Substituted anthranilic amide derivatives and methods of use | AADAC, ASPH, EGLN3 | MAPK8 1267/4885EGFR 1056/4885DAPK3 2176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.