Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11213892 | 1.00 | CYP19A1 (0.50) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL7696997 | 1.00 | CYP19A1 (0.50) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL7787578 | 0.98 | CYP19A1 (0.48) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL30202589 | 0.91 | CYP19A1 (0.42) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL29250827 | 0.91 | CYP19A1 (0.42) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL29250829 | 0.91 | CYP19A1 (0.42) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL29723633 | 0.89 | CYP19A1 (0.41) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL25456950 | 0.88 | TSHR (0.61) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL29723280 | 0.87 | TSHR (0.59) | CYP19A1TSHRCYP3A4SMN1; SMN2HTT | |
| SCHEMBL6359586 | 0.84 | TSHR (0.57) | TSHRSMN1; SMN2HTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1310487-B1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI SEIYAKU CO (JP) | 2007-01-03 | — | — | EP | disclosed |
| US-7074837-B2 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. | 2005-12-08 | — | — | US | disclosed |
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1310487-A1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-14 | — | — | EP | disclosed |
| EP-0829473-B1 | PROCESSES FOR PREPARING CYCLIC COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2002-08-07 | — | — | EP | disclosed |
| US-6334988-B1 | HEATING MINERAL ACID SUCH AS HYDROCHLORIC ACID, INORGANIC OXIDE SOURCE SUCH AS TETRAETHOXYSILANE, SURFACTANT SUCH AS CETYLTRIMETHLYAMMONIUM BROMIDE | THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE | 2002-01-01 | — | — | US | disclosed |
| EP-1148047-A2 | Processes for preparing cyclic compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6218548-B1 | (TRIARYLMETHYL)AMINOSPIROPYRROLES | DAIICHI PAHARMACEUTICAL CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| WO-2000010916-A1 | MESOPOROUS SILICATES AND METHOD OF MAKING SAME | UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 2000-03-02 | — | — | WO | disclosed |
| US-6013806-A | ANTIBACTEIRAL | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-01-11 | — | — | US | disclosed |
| US-5856518-A | Production process of cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| EP-0829473-A1 | PROCESSES FOR PREPARING CYCLIC COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, CYP51A1, WEE1 | CYP19A1 144/4885TSHR 4044/4885CYP3A4 38/4885 |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, WEE1, CYP51A1 | CYP19A1 150/4885TSHR 4000/4885CYP3A4 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.