Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | DGKA | P23743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26006 | 0.86 | CYP1A2 (0.50) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL11074412 | 0.80 | GAA (0.48) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11065818 | 0.78 | GAA (0.46) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL11609561 | 0.71 | KMT2A (0.57) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL7309740 | 0.69 | GAA (0.52) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL13250492 | 0.69 | GAA (0.46) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL20937053 | 0.68 | LTA4H (0.54) | KMT2AGAAPOLBCYP1A2ALDH1A1 | |
| SCHEMBL15493832 | 0.67 | MGAM (0.46) | KMT2AGAAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL4464939 | 0.67 | GAA (0.59) | KMT2AGAAPOLBL3MBTL1CYP1A2 | |
| SCHEMBL495925 | 0.67 | CYP1A2 (0.70) | KMT2AGAACYP1A2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802644-A2 | RNAI MODULATION OF APOB AND USES THEREOF | Alnylam Pharmaceuticals Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036916-A2 | RNAI MODULATION OF APOB AND USES THEREOF | ALNYLAM PHARMACEUTICALS, INC. (US) | 2006-04-06 | — | — | WO | disclosed |